FORECAST · GRANT
Funding Opportunity Announcement for Impact of Environmental Exposures on Gut-Brain Signaling in Neurological Conditions (R01)
- Expected deadline
- Not stated
- Who can apply
- Others
- Award range
- Not stated
- Expected awards
- 8
- Total program funding
- $4.0 million
- Your own money required
- No cost sharing or matching required
- Opportunity number
- TEMP-31126
- Posted
- Jul 18, 2025
- Assistance listing
- 93.113
More on who can apply
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
What it funds
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research that builds on our understanding of the gut microbiome-brain axis for the purpose of identifying improved detection, prevention, and intervention strategies for environmental exposure-induced neurological diseases. Given the overlapping gut-brain signaling pathways and the prevalence of neurological conditions with gut-related comorbidities, the scope of this program would be inclusive of a wide range of neurological outcomes, including mental health disorders and chronic neurodegenerative conditions such as Parkinson’s disease and Alzheimer’s disease. The objective of this program is to develop gut-focused intervention strategies (e.g., probiotics, microbial biomarkers, nutritional supplements and novel therapeutics) to decrease risk, slow progression, or possibly reverse these neurological condition(s). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of biological mechanisms underlying the effects of environmental exposures on neurological outcomes and the mediating role of the gut-brain axis are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in toxicology, microbiome, and neuroscience will be encouraged and these investigators should also begin considering applying for this application.
Open the official notice on Grants.gov ↗What to do next
- This is a forecast: the agency expects to post the full notice later. Open it on Grants.gov and subscribe there to be told when it posts.
- Get your SAM.gov registration ("all awards") and Grants.gov account active now; both take time.
- Use the forecast's award range and eligibility to decide whether to prepare.
- Watch for the notice; the dates here are estimates and can change.
New to this? Applying for a federal grant, step by step · Register to apply · How to read the notice · Write the narrative · Build the budget · Agency contact: anika.dzierlenga@nih.gov
From Grants.gov's official daily extract of Oct 25, 2026. The notice on Grants.gov and its attachments are what count. UX Contract is independent and not a government website.