Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

Deadline

Dec 14, 2026 (51 days left)

Who can apply

Others

Award range

Up to $1.5 million

Expected awards

5

Total program funding

$10 million

Your own money required

No cost sharing or matching required

Opportunity number

RFA-HG-27-009

Posted

Oct 9, 2026

Assistance listing

93.172

More on who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subco

What it funds

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, interaction centers will first propose a research framework to investigate whether interactions with effects beyond additive are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions and share their data as well as analyses through the Impact of Genomic Variation on Function (IGVF) portal and catalog. Centers will share their method for predicting the most important combinations for future testing. The rationale for this combination of research and resource work is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of genome-wide association studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.

What to do next

1. Open the official notice on Grants.gov and download the full announcement (the NOFO) and any attachments.
2. Check you can apply: the eligible applicants above, and any detail in the notice's eligibility section.
3. Register your organization in SAM.gov (choose "all awards") and create a Grants.gov account; allow several weeks the first time.
4. Apply through Grants.gov exactly as the notice says, before Dec 14, 2026. Late applications are usually not accepted.

New to this? Applying for a federal grant, step by step · Register to apply · How to read the notice · Write the narrative · Build the budget · Agency contact: nhgri-igvf@mail.nih.gov

From Grants.gov's official daily extract of Oct 25, 2026. The notice on Grants.gov and its attachments are what count. UX Contract is independent and not a government website.