FORECAST · COOPERATIVE AGREEMENT
Selective Precision Targeting (SPoT)
- Expected deadline
- Not stated
- Who can apply
- Small businesses
- Award range
- Not stated
- Expected awards
- 5
- Total program funding
- $1.5 million
- Your own money required
- No cost sharing or matching required
- Opportunity number
- FOR-TR-27-003
- Posted
- Jun 27, 2025
- Assistance listing
- 93.350
What it funds
The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor.More specifically, the initiative goals are to:Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interestAssess biodistribution and off-target effects using a multi-organ microphysiological systemProvide evidence of functional cargo activityDetermine optimal route of administrationGrant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.
Open the official notice on Grants.gov ↗What to do next
- This is a forecast: the agency expects to post the full notice later. Open it on Grants.gov and subscribe there to be told when it posts.
- Get your SAM.gov registration ("all awards") and Grants.gov account active now; both take time.
- Use the forecast's award range and eligibility to decide whether to prepare.
- Watch for the notice; the dates here are estimates and can change.
New to this? Applying for a federal grant, step by step · Register to apply · How to read the notice · Write the narrative · Build the budget · Agency contact: passley.hargrove@nih.gov
From Grants.gov's official daily extract of Oct 25, 2026. The notice on Grants.gov and its attachments are what count. UX Contract is independent and not a government website.